Top 100 Medical Device Companies (Free Chart Included)

Have you ever wondered about the biggest medical device companies in the world?

Maybe you're looking for a publicly traded medical device, medical instrument, or biotechnology company that might want to acquire your company or license your research, or perhaps you're looking for a publicly traded medical device company to invest in?

In this exclusive piece of content, we're bringing you a list of the top 100 medical device companies from around the world. This list is intended to help you answer important questions like:

• What are the top 100 medical device companies in the world by market cap?

• Which medical device companies spend the most money on R&D?

• Which medical device companies employ the most people around the world?

• Which medical device companies bring in the most revenue?

How We Researched the Top 100 Medical Device Companies

To gather the information, we researched the most recent annual report from each of the 100 medical device companies. Publicly traded companies must release their financial data, including total revenue and total R&D spending, in annual and quarterly reports. These companies end their fiscal year at different times, and the reports used in compiling this list were published on 03/30/2019, 09/30/2018, or 12/31/2018.

The market caps, a measure of the value of all stocks available for that company, are current as of March 2020. Companies are often classified in terms of their market cap as follows:

• Mega-cap medical device companies have a market cap in excess of $200 billion.

• Large-cap medical device companies have a market cap of $10 billion to $200 billion.

• Mid-cap medical device companies have a market cap of $2 billion to $10 billion.

• Small-cap medical device companies have a market cap of $300 million to $2 billion.

• Micro-cap medical device companies have a market cap of $50 million to $300 million.

For complete financial information on these medical device companies, navigate to the investor information in each of the site links, and download the annual report. You'll be able to learn more about your chosen company, including expenses, profits, and cash flow statements.

How to Use This Research on Medical Device Companies

You can use this research to develop a broader view of the global medical devices marketplace and get to know the biggest medical device companies in the industry. This information can help you:

• Discover companies developing technology that you may want to work on or that you could benefit from 

• Find a strategic partner or a larger firm that may want to acquire your business or research

• Evaluate the amount of revenue generated globally by medical device sales each year, especially by the industry giants that control large portions of the market

Let’s take a look at the top 100 medical device companies in 2020:

With our exclusive research, you'll be able to:

• Review the largest medical device companies in the world by market cap
• Develop a broader view of the medical devices global marketplace, the biggest players in the industry and the products and innovations making the biggest impacts today
• Discover companies developing technology that you may want to work on, or that you could benefit from
• Find a strategic partner or a larger firm that may want to acquire your business or research
• Appreciate the amount of revenue generated globally by medical device sales each year, especially by the industry giants that control huge amounts of market share
• Get links to each company's website where you can look up additional product information along with financial data and annual reports.

Free Bonus Giveaway: Click here to download our exclusive chart of the top 100 medical device companies in the world.

Overview of the Top 100 Medical Device Companies

JOHNSON & JOHNSON (NYSE: JNJ)

Total Revenue: $82.06B USD

Market Cap: $368.91B USD

R&D Spend: $11.4B USD

Employee Size: 132,200

Website: http://www.jnj.com/

Johnson & Johnson is a medical device, pharmaceutical, and consumer packaged-goods company founded in 1886. Headquartered in New Brunswick, New Jersey, the corporation operates 250 subsidiary companies in 60 countries and sells products in 175 countries. It is also the largest independent biotech firm in the world by market cap.

NOVARTIS AG (NYSE: NVS)

Total Revenue: $49.49B USD

Market Cap: $199.09B USD

R&D Spend: $8.1B USD

Employee Size: 103,941

Website: https://www.novartis.com

Novartis International AG is a Swiss multinational pharmaceutical company based in Basel, Switzerland. It is one of the largest pharmaceutical companies by both market capitalization and sales, and it is the third-largest Swiss company by revenue. The company’s several divisions design, manufacture, and sell medical devices across a wide range of applications, but the company might be best known for its Alcon vision, which focuses on eye-care products for cataracts, glaucoma, and refractive surgery and on disposable vision-corrective products.

ABBOTT LABORATORIES (NYSE: ABT)

Total Revenue:$30.6B USD

Market Cap: $143.91B USD

R&D Spend: $2.3B USD

Employee Size: 103,000

Website: http://www.abbott.com

Abbott Laboratories is an American health care company with headquarters in Abbot Park,Ilinois. The massive firm is operated in seven industrial divisions – Abbott Diabetes Care, Abbott Diagnostics Division, Abbott Molecular Diagnostics, Abbott Nutrition International, Abbott Point-of-care, Abbott Vascular Division, and Established Pharmaceuticals Division. A truly global company, Abbott does business in over 150 countries around the world.

MEDTRONIC PLC (NYSE: MDT)

Total Revenue: $30.56B USD

Market Cap: $137.53B USD

R&D Spend: $2.33B USD

Employee Size: 101,000

Website: https://www.medtronic.com/

Medtronic PLC is a medical device company. Its headquarters are in Dublin, Ireland. Its operational headquarters are in Fridley, Minnesota. Medtronic is among the world's largest medical equipment development companies. Its extensive product line includes patient care and monitoring accessories of all kinds; general surgical equipment; and medical devices for cardiovascular, diabetic, and neurological applications.

BAXTER INTERNATIONAL (NYSE: BAX)

Total Revenue: $11.1B USD

Market Cap: $129B USD

R&D Spend: $655M USD

Employee Size: 50,000

Website: https://www.baxter.com/

Baxter International Inc. provides a portfolio of health care products. The company operates throughout North America and South America, Europe, Africa, and the Middle East, and Asia-Pacific segments. It offers peritoneal dialysis and hemodialysis, and additional dialysis therapies and services; renal replacement therapies and other organ support therapies focused in the intensive care unit; sterile intravenous (IV) solutions, IV therapies, infusion pumps, administration sets, and drug reconstitution devices; and parenteral nutrition therapies. Baxter International Inc. was founded in 1931 and is headquartered in Deerfield, Illinois.

DANAHER CORPORATION (NYSE: DHR)

Total Revenue: $19.89B USD

Market Cap: $104.92B USD

R&D Spend: $1.23B USD

Employee Size: 71,000

Website: http://www.danaher.com/

The Danaher Corporation is a globally diversified conglomerate headquartered in Washington, D.C. Danaher is number 160 on the Fortune 500 list. Its products are concentrated in the fields of design, manufacturing, and marketing of industrial, health care, and consumer products. It operates in four segments: environmental and applied solutions, life sciences, diagnostics, and dental.

GENERAL ELECTRIC (NYSE: GE)

Total Revenue: $95.21B USD

Market Cap: $97.98B USD

R&D Spend: $4.16B USD

Employee Size: 205,000

Website: https://www.ge.com/

GE Healthcare provides transformational medical technologies and services that are shaping a new age of patient care. The company’s expertise in electrical systems has translated to industry-leading innovations in medical imaging and information technologies, diagnostics, patient monitoring, and manufacturing technologies. GE is one of the largest companies in the world by employee size, with 205,000 employees working around the world.

3M COMPANY (NYSE: MMM)

Total Revenue: $32.8B USD

Market Cap: $87.99B USD

R&D Spend: $1.8B USD

Employee Size: 93,516

Website: https://www.3m.com/

The 3M Company, formerly known as the Minnesota Mining and Manufacturing Company, is an American multinational conglomerate corporation operating in the fields of industry, health care, and consumer goods. 3M’s innovative health care brands include Cavilon, Clarity, Coban, CodeFinder, FUTURO, Littmann, Peltor, Petrifilm, Tegaderm, and Unitek. The company builds medical devices, food-safety testing products, and health information systems.

SIEMENS HEALTHINEERS (ETR: SHL)

Total Revenue: €14.5B EUR

Market Cap: $87.87B USD

R&D Spend: €1.32B EUR

Employee Size: 52,000

Website: https://www.healthcare.siemens.com/

Siemens Healthineers is a medical technology company headquartered in Erlangen, Germany. The company was founded in 1847 in Berlin by Ernst Werner von Siemens. Siemens is enabling health care providers to expand precision medicine and improve the patient experience by digitizing health care. The company has 170 years of experience and 65,000 patents around the world.

STRYKER CORPORATION (NYSE: SYK)

Total Revenue: $13.6B USD

Market Cap: $73.87B USD

R&D Spend: $856M USD

Employee Size: 36,000

Website: http://www.stryker.com/

Stryker Corporation is a Fortune 500 medical technologies firm based in Kalamazoo, Michigan. Stryker's products include implants used in joint replacement and trauma surgeries; surgical equipment and surgical navigation systems; endoscopic and communications systems; patient handling and emergency medical equipment; neurosurgical, neurovascular, and spinal devices; and other medical device products used in a variety of medical specialties.

BECTON, DICKINSON AND COMPANY (NYSE: BDX)

Total Revenue: $17.3B USD

Market Cap: $66.52B USD

R&D Spend: $1.06B USD

Employee Size: 70,093

Website: http://www.bd.com/

Becton, Dickinson and Company develops, manufactures, and sells medical supplies, devices, laboratory equipment, and diagnostic products worldwide. It operates in two segments: BD Medical and BD Life Sciences. The company markets its products through independent distribution channels and sales representatives to health care institutions, life science researchers, clinical laboratories, the pharmaceutical industry, and the general public. Becton, Dickinson and Company was founded in 1897 and is based in Franklin Lakes, New Jersey.

INTUITIVE SURGICAL INC. (NASDAQ: ISRG)

Total Revenue: $3.08B USD

Market Cap: $64.84B USD

R&D Spend: $418 USD

Employee Size: 5,527

Website: http://www.intuitivesurgical.com/

Intuitive Surgical Inc. is a global technology leader in minimally invasive robotic-assisted surgery. The company's da Vinci Surgical System enables surgeons to operate in a minimally invasively way through a few small incisions while positioned at a nearby ergonomic console. The da Vinci System features a magnified 3D HD vision system with instruments that bend and rotate far greater than that possible by the human hand. As a result of this technology, da Vinci enables surgeons to operate with enhanced vision, precision, and control.

ALLERGAN PLC (NYSE: AGN)

Total Revenue: $15.78B USD

Market Cap: $63.77B USD

R&D Spend: $2.22B USD

Employee Size: 16,900

Website: https://www.allergan.com/

Allergan PLC is a multinational company that produces branded drugs and performs pharmaceutical research and development. Allergan markets a portfolio of leading brands and best-in-class products for eye care, medical aesthetics and dermatology, gastroenterology, women's health, urology, anti-infective therapeutic categories, and the central nervous system. Allergan is an industry leader in Open Science, the company’s R&D model, which defines its approach to identifying and developing game-changing ideas and innovation for better patient care. This approach has led to Allergan building one of the broadest development pipelines in the pharmaceutical industry.

HOYA CORPORATION (TYO: 7741)

Total Revenue: ¥565.81B JPY

Market Cap: ¥3.49T JPY

R&D Spend: ¥28B JPY

Employee Size: 34,635

Website: http://www.hoya.com/

Hoya Corporation is a Japanese medical technology company that manufactures a range of eyewear products. The company has a range of contacts and glasses created with wavefront technology for the health care market. Hoya also creates medical photonics and other products. The company is a Forbes Global 2,000 Technology Companies and acquired Pentax in 2007 for $1 billion USD.

BOSTON SCIENTIFIC CORPORATION (NYSE: BSX)

Total Revenue: $9.82B USD

Market Cap: $55.43B USD

R&D Spend: $1.13B USD

Employee Size: 32,000

Website: http://www.bostonscientific.com/

Boston Scientific Corporation, doing business as Boston Scientific, is a manufacturer of medical devices used in interventional medical specialties, including interventional radiology, interventional cardiology, peripheral interventions, neuromodulation, neurovascular intervention, electrophysiology, cardiac surgery, vascular surgery, endoscopy, oncology, urology, and gynecology.

Boston Scientific is primarily known for the development of the Taxus stent, a drug-eluting stent, which is used to open clogged arteries.

EDWARDS LIFESCIENCES CORP (NYSE: EW)

Total Revenue: $3.8B USD

Market Cap: $44.53B USD

R&D Spend: $646M USD

Employee Size: 13,000

Website: http://www.edwards.com/

Edwards Lifesciences Corporation, incorporated on September 10, 1999, is a manufacturer of heart-valve systems and repair products used to replace or repair a patient's diseased or defective heart valve. The company is globally engaged in patient-focused innovations for structural heart disease and critical care monitoring. Its segments include the United States, Europe, Japan, and the rest of the world. Its products are categorized into three areas: Transcatheter Heart Valve Therapy, Surgical Heart Valve Therapy, and Critical Care. It also develops hemodynamic monitoring systems that are used to measure a patient's cardiovascular function in the hospital setting.

KONINKLIJKE PHILIPS N.V. (AEX: PHIA)

Total Revenue: €19.5B EUR

Market Cap: €38.63B EUR

R&D Spend: €1.88B EUR

Employee Size: 80,495

Website: https://www.philips.com/global

Koninklijke Philips (NYSE: PHG, AEX: PHIA) is a leading health technology company focused on improving people's health and enabling better outcomes across the health continuum, from healthy living and prevention to diagnosis, treatment, and home care. Philips leverages advanced technology and deep clinical and consumer insights to deliver integrated solutions. Headquartered in the Netherlands, the company is a leader in diagnostic imaging, image-guided therapy, patient monitoring, and health informatics, as well as in consumer health and home care. Philips' health technology portfolio generated sales of EUR 19.5 billion in 2019 and employs approximately 80,495 employees, with sales and services in more than 100 countries.

DRAEGERWERK AG & CO KGAA (ETRL: DRW3)

Total Revenue: €2.59B EUR

Market Cap: €30.16B EUR

R&D Spend: €780.75

Employee Size: 173

Website: https://www.draeger.com

Draegerwerk AG & CO KGAA is a German medical device company that makes breathing and protection equipment as well as systems for gas detection, analysis systems, and noninvasive patient-monitoring technologies. The company has sales and subsidiaries in 50 countries and is represented worldwide.

COLOPLAST A/S (CPH: COLO-B)

Total Revenue: $17.93B DKK

Market Cap: $29.29B USD

R&D Spend: $692M DKK

Employee Size: 11,821

Website: https://www.coloplast.com/

Coloplast A/S is a Denmark-based company active within the health care sector. It is engaged in the development, marketing, and sale of intimate health care products and services, targeting people with diseases of a private or personal nature. Its operations are divided into four business areas: Ostomy Care, offering products for people whose intestinal outlet has been rerouted through the abdominal wall; Continence Care, offering products for people suffering from diseases of and damage to the urinary system; Urology Care, offering products for people suffering from diseases of and damage to the kidneys, the urinary system, or the male reproductive system; and Wound & Skin Care, offering products for the treatment of chronic wounds, as well as skin care products. The company supplies products to hospitals, institutions, wholesalers, and pharmacies.

ZIMMER BIOMET HOLDINGS (NYSE: ZBH)

Total Revenue: $7.93B USD

Market Cap: $28.74B USD

R&D Spend: $388M USD

Employee Size: 19,000

Website: http://www.zimmerbiomet.com/

Zimmer Biomet was founded in 1927 to produce aluminum splints and is part of the medical devices business cluster in Warsaw, Indiana. The company’s core business includes the design, development, and manufacturing of orthopedic products – knee, hip, shoulder, elbow, and ankle artificial joints and prosthetic dental devices. Zimmer operates in 40+ countries around the world and has grown largely through acquisitions, most recently that of Biomet Inc. in 2014 for $13.4 billion.

FRESENIUS MEDICAL CARE AG & CO. KGAA (NYSE: FMS)

Total Revenue: €16.54B EUR

Market Cap: €25.67B EUR

R&D Spend: €134M EUR

Employee Size: 112,658

Website: https://fmcna.com

Fresenius Medical Care AG & Co. KGaA, a kidney dialysis company, provides dialysis care and related services and other health care services. It offers dialysis treatment and related laboratory and diagnostic services through a network of outpatient dialysis clinics; materials, training, and patient support services comprising clinical monitoring, follow-up assistance, and arranging for delivery of the supplies to the patient's residence; and dialysis services under contract to hospitals in the United States for patients hospitalized with end-stage renal disease (ESRD) and for patients suffering from acute kidney failure.

OLYMPUS CORPORATION (TYO: 7733)

Total Revenue: ¥793.9 B JPY

Market Cap: $25.18B USD

R&D Spend: ¥84.57B JPY

Employee Size: 35,124

Website: http://www.olympus-global.com/

Olympus Corporation is a Japanese manufacturer of optics and reprography products. Olympus was established on October 12, 1919, and initially specialized in microscopes and thermometers. Today, the company earns the majority of its annual revenue through its medical device business, with the remaining coming from its scientific solutions and imaging departments. Olympus primarily manufactures and sells endotherapy devices, surgical devices, and endoscopes.

TERUMO CORPORATION (TYO: 4543)

Total Revenue: ¥587.8B JPY

Market Cap: $25.09B USD

R&D Spend: ¥41.34M JPY

Employee Size: 23,319

Website: http://www.terumomedical.com

Dr. Shibasaburo Kitasato and other physicians founded Terumo in 1921, when importation of medical thermometers ceased in the aftermath of World War I, spurring the need to manufacture the instruments domestically. Over the years, Terumo has provided new value by grappling with health care issues in areas such as infection control, prevention of medical errors, the demand for minimally invasive treatments, and improvements in both medical cost efficiency and patient quality of life (QOL). The Terumo Group now conducts business in over 160 nations, expanding the concept of “society” to embrace a global perspective.

RESMED INC. (NYSE: RMD)

Total Revenue: $2.6B USD

Market Cap: $24.4B USD

R&D Spend: $180.6M USD

Employee Size: 7,240

Website: http://www.resmed.com/

ResMed Inc., incorporated on March 31, 1994, is a holding company. The company is engaged in the development, manufacturing, distribution, and marketing of medical devices and cloud-based software applications that diagnose, treat, and manage respiratory disorders, including sleep-disordered breathing (SDB), chronic obstructive pulmonary disease (COPD), neuromuscular disease, and other diseases.

SMITH & NEPHEW PLC (NYSE: SNN)

Total Revenue: $4.9B USD

Market Cap: $20.21B USD

R&D Spend: $246M USD

Employee Size: 16,000

Website: http://www.smith-nephew.com/

Smith & Nephew PLC has a history dating back 160 years to the family enterprise of Thomas James Smith, who opened a small pharmacy in Hull, England, in 1856. Upon his death, in 1896, his nephew, Horatio Nelson Smith, took over the management of the business. A few days after the declaration of World War I, in 1914, Horatio Nelson Smith met with an envoy of the French president in London. Smith & Nephew PLC was awarded a contract to supply £350,000 of surgical and field dressings, to be delivered in five months.

Today, the company has grown rapidly through acquisitions and is listed in the FTSE-100, an index fund comprising the largest 100 companies on the London Stock Exchange by market cap.

ALIGN TECHNOLOGY (NASDAQ: ALGN)

Total Revenue: $1.9B USD

Market Cap: $18.13B USD

R&D Spend: $128.9M USD

Employee Size: 11,600

Website: http://www.aligntech.com/

Align Technology is a manufacturer of 3D digital scanners and clear aligners used in orthodontics. It is headquartered in San Jose, California. It manufactures the aligners in Juarez, Mexico, and its scanners in Israel. In 1999, Align Technology pioneered the invisible orthodontics market with the introduction of the Invisalign system and by 2001 had manufactured 1 million unique clear aligners. The Invisalign system is offered to adult and teenage patients by Invisalign-trained doctors in more than 90 countries worldwide.

THE COOPER COMPANIES INC. (NYSE: COO)

Total Revenue: $2.53B USD

Market Cap: $16.49B USD

R&D Spend: $75M USD

Employee Size: 12,000

Website: http://www.coopercos.com/

The Cooper Companies Inc., incorporated on March 4, 1980, is a global medical device company. The company operates through two business units: CooperVision Inc. and CooperSurgical Inc. CooperVision offers soft contact lenses for the vision-correction market. CooperSurgical offers an array of products and services focused on advancing the health of families through a portfolio of products and services geared towards women's health, fertility, and diagnostics.

CooperVision develops, manufactures, and markets a range of single-use, two-week, and monthly contact lenses, featuring various materials and optics. CooperVision's products are designed to solve vision challenges, such as astigmatism, presbyopia, ocular dryness, and eye fatigue, with a collection of spherical, toric, and multifocal contact lenses.

TELEFLEX INC. (NYSE: TFX)

Total Revenue: $2.44B USD

Market Cap: $16.39B USD

R&D Spend: $106.2 USD

Employee Size: 15,200

Website: http://www.teleflex.com/

Teleflex Inc., incorporated on June 25, 1943, is a provider of medical technology products. The company primarily designs, develops, manufactures, and supplies single-use medical devices used by hospitals and health care providers for common diagnostic and therapeutic procedures in critical care and surgical applications. The company operates through six segments: Vascular North America; Anesthesia North America; Surgical North America; Europe, Middle East, Africa (EMEA); Asia; and Original Equipment Manufacturer and Development Services.

CARDINAL HEALTH INC. (NYSE: CAH)

Total Revenue: $145.5B USD

Market Cap: $15.76B USD

R&D Spend: None

Employee Size: 49,500

Website: https://www.cardinalhealth.com/

Cardinal Health offers distribution, inventory management, data reporting, new product launch support, and charge-back administration services to pharmaceutical manufacturers; pharmacy and medication therapy management, and patient outcomes services to hospitals, other health care providers, and payers; and consulting, patient support, and other services to pharmaceutical manufacturers and health care providers. Cardinal Health Inc. was founded in 1979 and is headquartered in Dublin, Ohio.

STRAUMANN HOLDING AG (STMN.SW)

Total Revenue: 1.59B CHF 

Market Cap: $15.09B

R&D Spend: None

Employee Size: 7,590

Website: https://www.straumann.com/

Straumann conducts research with leading universities, and manufactures dental implants and a host of other products in the dental industry. Because technological advancements are changing dentistry fundamentally, Straumann offers a broad range of products and solutions for both conventional treatment and digital workflows, including guided surgery, intraoral scanning, and CAD/CAM restorations.

STERIS PLC (NYSE: STE)

Total Revenue: $2.78B USD

Market Cap: $13.86B USD

R&D Spend: $63.03M USD

Employee Size: 12,000

Website: https://www.steris.com/

Steris PLC provides infection prevention and other procedural products and services. The company operates through four segments: health care products, which offers infection prevention and procedural solutions for health care providers, including capital equipment and related maintenance, installation services, and consumables; health care specialty services, which provides a range of specialty services for health care providers, including hospital sterilization services, instrument and scope repairs, and linen management; Life Sciences, which offers capital equipment and consumable products, and equipment maintenance and specialty services for pharmaceutical manufacturers and research facilities; and Applied Sterilization Technologies, which offers contract sterilization and laboratory services for medical device and pharmaceutical customers and others.

FREE RESOURCE: Click here to download a PDF chart of the top 100 medical device companies in the world.

HOLOGIC INC. (NASDAQ: HOLX)

Total Revenue: $3.21B USD

Market Cap: $12.85B USD

R&D Spend: $218.7M USD

Employee Size: 6,252

Website: http://www.hologic.com/

Hologic Inc., incorporated on January 18, 1990, is a developer, manufacturer, and supplier of diagnostics products, medical imaging systems, and surgical products, with an emphasis on women's health. The company operates through four segments: Diagnostics, Breast Health, GYN Surgical, and Skeletal Health. The company sells and services its products through a combination of direct sales and service personnel and a network of independent distributors and sales representatives.

WATERS CORPORATION (NYSE: WAT)

Total Revenue: $2.41B USD

Market Cap: $12.6B USD

R&D Spend: $143M USD

Employee Size: 7,200

Website: http://www.waters.com/

Waters Corp., a publicly traded corporation (NYSE: WAT) headquartered in Milford, Massachusetts, holds leading positions worldwide in complementary analytical technologies — liquid chromatography, mass spectrometry, rheometry, and microcalorimetry.

Specifically, the company designs, manufactures, sells, and services ultra-performance liquid chromatography (UPLC), high-performance liquid chromatography (HPLC), chromatography columns and chemistry products, mass spectrometry (MS) systems, thermal analysis, and rheometry instruments.

Waters Corp. operates in two divisions: Waters Division and TA Instruments.

WEST PHARMACEUTICAL SERVICES INC. (NYSE: WST)

Total Revenue: $1.72B USD

Market Cap: $11.55BB USD

R&D Spend: $40.3M USD

Employee Size: 7,400

Website: https://www.westpharma.com/

West Pharmaceutical Services Inc., incorporated on July 27, 1923, is a manufacturer of packaging components and delivery systems for injectable drugs and health care products. The company's products include vial containment solutions, prefillable systems, self-injection platforms, cartridge systems and components, reconstitution and transfer systems, intradermal delivery solutions, specialty components, and contract manufacturing and analytical services.

VARIAN MEDICAL SYSTEMS INC. (NYSE: VAR)

Total Revenue: $2.61B USD

Market Cap: $11.47B USD

R&D Spend: $246M USD

Employee Size: 10,062

Website: http://www.varian.com/

Varian Medical Systems Inc., incorporated on January 22, 1976, is a manufacturer of medical devices and software for treating cancer and other medical conditions with radiotherapy, radiosurgery, proton therapy, and brachytherapy medical devices. The company also offers Varian Particle Therapy (VPT) and owns the Ginzton Technology Center (GTC). Its VPT business develops, designs, manufactures, sells, and services products and systems for delivering proton therapy, another form of external beam radiotherapy using proton beams for the treatment of cancer.

DENTSPLY SIRONA INC. (NASDAQ: XRAY)

Total Revenue: $3.98B USD

Market Cap: $11.04B USD

R&D Spend: $160.5M USD

Employee Size: 16,400

Website: https://www.dentsplysirona.com

DENTSPLY SIRONA Inc., incorporated on February 15, 1983, is a manufacturer of professional dental products and technologies. The company develops, manufactures, and markets solutions like dental and oral health products, as well as other consumable medical devices. The company operates through two segments: dental and health care consumables, and medical technology. The dental industry encompasses the diagnosis, treatment, and prevention of disease and ailments of the teeth, gums, and supporting bone. The company's principal dental product categories are dental consumable products, dental laboratory products, dental specialty products, and dental equipment. Additionally, the company's consumable medical device products are used for urological and surgical applications.

MASIMO CORPORATION (NASDAQ: MASI)

Total Revenue: $858M USD

Market Cap: $9.5BUSD

R&D Spend: $76.9M USD

Employee Size: 1,500

Website: http://www.masimo.com/

Masimo Corporation, incorporated on May 7, 1996, is a medical technology company that develops, manufactures, and markets a range of noninvasive patient-monitoring technologies. The company's business is measure-through motion and low perfusion pulse oximetry monitoring, known as Masimo Signal Extraction Technology (SET) pulse oximetry. Its product offerings include noninvasive monitoring of blood constituents with an optical signature, optical organ oximetry monitoring, and more.

SARTORIUS STEDIM BIOTECH S.A. (ETR: SRT)

Total Revenue: €1.93B EUR

Market Cap: €6.87B EUR

R&D Spend: €95.6M EUR

Employee Size: 9,016

Website: https://www.sartorius.com

Sartorius Stedim Biotech SA is a German-based international provider of laboratory and process technologies and equipment. The company covers the segments of biotechnology and mechatronics. Sartorius provides services that help customers implement complex and quality-critical processes in biopharmaceutical production and laboratory environments in a time- and cost-efficient way. The company’s customers are from the biotech, pharma, and food industries, as well as from public research institutes and laboratories. Sartorius operates its own production facilities in Europe, Asia, and America and also has sales offices and local representatives in more than 110 countries. The company operates through its subsidiaries, including Sartorius Stedim Austria GmbH, Sartorius Stedim Plastics GmbH, BioOutsource Ltd., and Wave Biotech AG, among others.

FISHER & PAYKEL HEALTHCARE CORPORATION LIMITED (NZE: FPH)

Total Revenue: $1.07B NZD

Market Cap: $15.28B NZD

R&D Spend: $428.2M NZD

Employee Size: 4,500

Website: https://www.fphcare.com/

Fisher & Paykel Healthcare Corporation Limited designs, manufactures, and markets medical device products and systems for use in respiratory care, acute care, and the treatment of obstructive sleep apnea. The company's segments include New Zealand, which includes all activities controlled by entities or employees based in New Zealand; North America, which includes all activities controlled by entities or employees based in the United States and Canada; Europe, which includes all activities controlled by entities or employees based in the United Kingdom, France, Germany, Sweden, Turkey, and Russia; and Asia-Pacific, which includes all activities controlled by entities or employees based in Australia, Japan, India, China, South Korea, Taiwan, and Hong Kong. Its products include respiratory humidifiers, single-use and reusable chambers and breathing circuits, infant resuscitators, infant warmers, and accessories. In addition, the company offers hardware and consumables.

COCHLEAR LIMITED (ASX: COH)

Total Revenue: $1.24B AUD

Market Cap: $12B AUD

R&D Spend: $184.4M AUD

Employee Size: 4,000

Website: https://www.cochlear.com/

Cochlear Limited is engaged in providing implantable hearing solutions. The company's implant systems comprise an implant, which is inserted during surgery, and an external sound processor. The company operates through three segments, based on geography: EMEA, Asia/Pacific, and the Americas. The Americas includes Canada, Latin America, and the United States. EMEA includes Europe, the Middle East, and Africa. Asia/Pacific includes Australasia and Asia. The company's products and solutions include cochlear implants, such as Nucleus 6 and Aqua+; bone conduction implants, such as Baha Attract and Baha Connect; acoustic implant solutions, such as the Cochlear Carina System, the Cochlear MET System, and the Cochlear Codacs System, and others. The company sells its products in over 100 countries.

ABIOMED INC. (NASDAQ: ABMD)         

Total Revenue: $769M USD

Market Cap: $6.99B USD

R&D Spend: $94M USD

Employee Size: 1,350

Website: http://www.abiomed.com/

Abiomed (NASDAQ: ABMD) is a leading provider of medical devices that provide circulatory support. Their products are designed to enable the heart to rest by improving blood flow and/or performing the pumping of the heart. CEO, chairman, and president Michael R. Minogue has focused the company’s efforts on developing groundbreaking technologies designed to improve patient outcomes focused on native heart recovery. Founded in 1981 to develop the world’s first artificial heart, Abiomed has remained dedicated to finding ways to bring the most advanced and beneficial technology to patients and physicians.

ASAHI INTECC CO. LTD. (TYO: 7747)

Total Revenue: ¥50.12B JPY

Market Cap: ¥734.13B JPY

R&D Spend: ¥12.3B JPY

Employee Size: 7,810

Website: http://www.asahi-intecc.co.jp/

Asahi Intecc Co. Ltd. was founded in Japan in 1976. The company specializes in making ultrafine stainless steel ropes for use in catheter treatment. The company also manufactures products for cardiovascular treatments. The company is headquartered in Nagoya and has six branches worldwide.

HILL-ROM HOLDINGS INC. (NYSE: HRC)

Total Revenue: $2.91B USD

Market Cap: $6.74B USD

R&D Spend: $139.5M USD

Employee Size: 10,000

Website: http://www.hill-rom.com/

Hill-Rom Holdings Inc., incorporated on August 7, 1969, is a global medical technology company. The company partners with health care providers across care settings by focusing on patient care solutions that improve clinical and economic outcomes in five core areas: advancing mobility; wound care and prevention; patient monitoring and diagnostics; surgical safety and efficiency; and respiratory health. Its segments include Patient Support Systems, Front Line Care, and Surgical Solutions.

AMPLIFON SPA (BIT: AMP)

Total Revenue: €1.37B EUR

Market Cap: €5.46B EUR

R&D Spend: None

Employee Size: 16,000

Website: https://www.amplifon.com/

Amplifon SpA is an Italy-based company engaged in the hearing systems industry. It distributes, adjusts, and personalizes hearing aids. It offers a generation of invisible hearing amplifiers, tiny electronic instruments that receive, process, and amplify sounds that are then transmitted to the ear, thanks to the instruments’ clear and precise amplification process. They are able to meet needs because they address a wide range of problems stemming from slight to serious hearing loss. The hearing aids ensure that listening quality is consistent as they adapt to different sound environments. The company operates through the following brands: Sonus, Miracle-Ear, Beter Horen, and Dialogue, among others.

HAEMONETICS CORPORATION (NYSE: HAE)

Total Revenue: $967M USD

Market Cap: $5.56B USD

R&D Spend: $35.7M USD

Employee Size: 3,216

Website: https://www.haemonetics.com/

Haemonetics Corporation, incorporated on August 29, 1985, is a health care company. The company provides various products to customers involved in the processing, handling, and analysis of blood. The company's segments include Japan, EMEA, North America Plasma, and the rest of the world. It provides plasma collection systems and software, enabling plasma fractionators to make pharmaceuticals. It provides analytical devices for measuring hemostasis, which enable health care providers to manage their patients' bleeding risk. Haemonetics makes blood processing systems and software, which tracks blood components.

SHANDONG WEIGAO GROUP MEDICAL POLYMER COMPANY LTD. (HKG: 1066)

Total Revenue: ¥8.8B CNY

Market Cap: $5.02B USD

R&D Spend: ¥311.6M CNY

Employee Size: 9,562

Website: http://en.weigaogroup.com/

Shandong Weigao Group Medical Polymer Co. Ltd. is principally engaged in the research and development, production, and sale of single-use medical devices. The company sells products under brands Jierui and Wego Ortho. The company operates through three business segments. The Single-Use Medical Device Products segment is engaged in the production and sale of single-use consumables, such as infusion sets, syringes, blood transfusion sets, and blood bags. The Orthopedic Products segment is engaged in the production and sale of orthopedic products. The Blood Purification Products segment is engaged in the production and sale of blood purification products and related medical equipment.

INSULET CORPORATION (NASDAQ: PODD)

Total Revenue: $738M USD

Market Cap: $10.85 USD

R&D Spend: $129.7M USD

Employee Size: 1,350

Website: http://www.insulet.com/

Insulet Corporation, incorporated on July 20, 2000, is engaged in the development, manufacture, and sale of the Omnipod Insulin Management System (the Omnipod System), an insulin delivery system for people with insulin-dependent diabetes. The Omnipod System eliminates the need for a bulky pump, tubing, and separate blood glucose meter; provide for virtually pain-free automated cannula insertion; communicate wirelessly; and integrate a blood glucose meter.

GLOBUS MEDICAL INC. (NYSE: GMED)

Total Revenue: $785.4M USD

Market Cap: $4.7B USD

R&D Spend: $60M USD

Employee Size: 1,800

Website: http://www.globusmedical.com/

Globus Medical Inc., incorporated on March 3, 2003, is a medical device company. The company is focused on developing products for patients with musculoskeletal disorders. It is focused on products to treat patients with spine disorders. The company's products fall under categories including Innovative Fusion and Disruptive Technologies. The products in the Innovative Fusion category include fusion products to treat spinal disorders for the entire spine, and they can be used in various surgical approaches. The Disruptive Technologies category represents a shift in the treatment of spinal disorders by allowing for surgical procedures and the treatment of spinal disorders.

GETINGE AB (CPH: GETI-B)

Total Revenue: 24.2B SEK

Market Cap: $4.68B USD

R&D Spend: 1.25B SEK

Employee Size: 10,515

Website: https://www.getinge.com

Getinge AB is a global medical technology company, founded in Sweden in 1904. The firm provides equipment and systems within health care and life sciences. Getinge is a leading global provider of products and systems that contribute to quality enhancement and cost efficiency within health care and life sciences. The company was organized into three distinct business areas: Infection Control (Getinge), Extended Care (ArjoHuntleigh) and Medical Systems (Maquet), but it was announced in March 2017 that the company would unify its brands under the Getinge name moving forward.

TANDEM DIABETES CARE INC. (NASDAQ: TNDM)

Total Revenue: $183.9M USD

Market Cap: $4.64B USD

R&D Spend: $8.7M USD

Employee Size: 643

Website: https://www.tandemdiabetes.com/

Tandem Diabetes Care Inc., incorporated on January 7, 2008, is a medical device company. The company is engaged in designing, developing, and commercializing products for people with insulin-dependent diabetes. The company manufactures and sells more than three insulin pump products in the United States that are designed to address the insulin-dependent diabetes market, which include t:slim Insulin Delivery System (t:slim), t:flex Insulin Delivery System (t:flex), and t:slim G4 Insulin Delivery System (t:slim G4). The company's technology platform features Micro-Delivery Technology, a miniaturized pumping mechanism that draws insulin from a flexible bag within the pump's cartridge rather than relying on a syringe-and-plunger mechanism.

INTEGRA LIFESCIENCES HOLDINGS CORPORATION (NASDAQ: IART)

Total Revenue: $1.47B USD

Market Cap: $4.44B USD

R&D Spend: $77.9M USD

Employee Size: 4,500

Website: https://www.integralife.com/

Integra LifeSciences Holdings Corporation, incorporated on June 19, 1989, is a medical technology company. The company focuses on the development, manufacturing, and marketing of surgical implants and medical instruments. The company's segments include Specialty Surgical Solutions and Orthopedics and Tissue Technologies. The company's products are used in neurosurgery, extremity reconstruction, orthopedics, and general surgery.

INOGEN INC. (NASDAQ: INGN)

Total Revenue: $361.9M USD

Market Cap: $4.311B USD

R&D Spend: $3.62M USD

Employee Size: 1,020

Website: https://www.inogen.com/

Inogen Inc., a medical technology company, primarily develops, manufactures, and markets portable oxygen concentrators in the United States and internationally. The company’s oxygen concentrators are used to deliver supplemental long-term oxygen therapy to patients suffering from chronic respiratory conditions. It offers Inogen One, a portable device that concentrates the air around the patient to provide a single source of supplemental oxygen; Inogen At Home stationary oxygen concentrators; and related accessories.

NEVRO CORP. (NYSE: NVRO)

Total Revenue: $387.2M USD

Market Cap:  $4.25B USD

R&D Spend: $48.45M USD

Employee Size: 804

Website: https://www.nevro.com/

Nevro Corp., incorporated on October 4, 2006, is a global medical device company. The company focuses on providing products that improve the quality of life of patients suffering from chronic pain. The company has developed and commercialized the Senza spinal cord stimulation (SCS) system, an evidence-based neuromodulation platform for the treatment of chronic pain. The company's HF10 therapy is designed to deliver neuromodulation solutions for treating chronic pain. HF10 therapy enables patients to achieve sustained pain relief without paresthesia, thus enabling patients to avoid the uncomfortable shocking or jolting sensations commonly associated with paresthesia.

ICU MEDICAL INC. (NASDAQ: ICUI)

Total Revenue: $1.4B USD

Market Cap: $4.15B USD

R&D Spend: $52.8M USD

Employee Size: 8,100

Website: http://www.icumed.com/

ICU Medical Inc., incorporated on January 9, 1992, is engaged in the development, manufacture, and sale of medical devices used in infusion therapy, oncology, and critical care applications. The company's product line includes needle-free connection devices; custom infusion sets; closed-system transfer devices (CSTD) for the handling of hazardous drugs; advanced sensor catheters; needle-free closed blood sampling systems; disposable pressure transducer systems; and hemodynamic monitoring systems. As of December 31, 2016, its products were used in acute care hospitals and ambulatory clinics in more than 65 countries throughout the world.

WRIGHT MEDICAL GROUP N.V. (NASDAQ: WMGI)

Total Revenue: $836M USD

Market Cap: $3.91B USD

R&D Spend: $59.1M USD

Employee Size: 2,894

Website: http://www.wright.com/

Wright Medical Group N.V. is a medical device company with segments including U.S. Lower Extremities & Biologics, U.S. Upper Extremities, and International Extremities & Biologics. As of 2019, the company markets hundreds of products in over 50 countries worldwide. Wright Medical Group makes biologics and sport medicine products, as well as products for upper and lower extremities. Wright Medical Group acquired Cartiva Inc. for $435 million USD in 2018. 

MICROPORT SCIENTIFIC CORPORATION (HKG: 0853)

Total Revenue: $669.49M USD

Market Cap: $3.828B HKD

R&D Spend: $104.8M USD

Employee Size: 5,000

Website: http://www.microport.com/

MicroPort Scientific Corporation is a Hong Kong-based investment holding company principally engaged in the manufacture and sale of medical products. The company operates through seven segments. The Orthopedics Devices segment researches, develops, manufactures, and sells orthopedics devices. The Cardiovascular Devices segment researches, develops, manufactures, and sells cardiovascular devices, such as drug-eluting stents. The Endovascular Devices segment researches, develops, manufactures, and sells endovascular devices. The Electrophysiology Devices segment researches, develops, manufactures, and sells electrophysiology devices. The Neurovascular Devices segment researches, develops, manufactures, and sells neurovascular devices. The Surgical Management segment researches, develops, manufactures, and sells surgical devices. The Diabetes Care and Endocrine Management segment researches, develops, manufactures, and sells devices related to diabetes mellitus.

NUVASIVE (NASDAQ: NUVA)

Total Revenue: $1.1B USD

Market Cap: $3.42B USD

R&D Spend: $61M USD

Employee Size: 2,600

Website: http://www.nuvasive.com/

NuVasive Inc., incorporated on July 21, 1997, is a medical device company. The company focuses on developing minimally disruptive surgical products and procedurally integrated solutions for spine surgery. The company's product portfolio focuses on applications for spinal-fusion surgery, including biologics used to aid in the spinal-fusion process. The company's principal product offering includes a minimally disruptive surgical platform called Maximum Access Surgery (MAS).

CONMED CORPORATION (NYSE: CONMED)

Total Revenue: $859.63M

Market Cap: $2.78B USD

R&D Spend: $42.1M USD

Employee Size: 3,100

Website: http://www.conmed.com/

CONMED Corporation, incorporated on February 10, 1970, is a medical technology company. The company is, engaged on a global basis, in the development, manufacture, and sale of surgical devices and related equipment. The company provides surgical devices and equipment for minimally invasive procedures. The company's products are used by surgeons and physicians in a range of specialties, including orthopedics, general surgery, gynecology, neurosurgery, and gastroenterology. The company's product lines consist of orthopedic surgery, general surgery, and surgical visualization. The company's products are distributed domestically directly to thousands of hospitals, surgery centers, and other health care institutions, as well as through medical specialty distributors.

GERRESHEIMER AG (ETR: GXI)

Total Revenue: €1.34B EUR

Market Cap: €2.13B EUR

R&D Spend: None

Employee Size: 9,872

Website: https://www.gerresheimer.com/

Gerresheimer AG is a Germany-based company that is active in the pharmaceuticals and health care industries. The company operates through two business segments: Plastics and Devices, and Primary Packaging Glass. The Plastics and Devices segment produces standard and customized products for drug delivery, such as insulin pens, inhalers, and prefillable syringes. The Primary Packaging Glass segment focuses on the production of packaging of glass for medicines and cosmetics, such as pharmaceutical jars, ampoules, injection vials, cartridges, perfume flacons, and cream jars, as well as glass containers for the food and beverage industry. The company operates approximately 40 production facilities in Europe, North America, South America, and Asia.

MERIT MEDICAL SYSTEMS (NASDAQ: MMSI)

Total Revenue: $882.7M USD

Market Cap: $2.04B USD

R&D Spend: $59.53M USD

Employee Size: 5,783

Website:  https://www.merit.com/ 

Merit Medical Systems Inc., incorporated on July 28, 1987, is a manufacturer and marketer of disposable medical devices used in a range of interventional, diagnostic, and therapeutic medical procedures. The company operates in two segments: cardiovascular and endoscopy. The cardiovascular segment consists of cardiology and radiology devices, which assist in diagnosing and treating coronary arterial disease, peripheral vascular disease, and other nonvascular diseases, and includes embolotherapeutic, cardiac rhythm management (CRM), electrophysiology (EP), and interventional oncology and spine devices. Its endoscopy segment consists of gastroenterology and pulmonology medical devices, which assist in the palliative treatment of expanding esophageal, tracheobronchial, and biliary strictures caused by malignant tumors.

PRESTIGE BRANDS HOLDINGS (NYSE: PBH)

Total Revenue: $975.77M USD

Market Cap: $1.93B USD

R&D Spend: None

Employee Size: 530

Website: http://prestigebrands.com/

Prestige Brands Holdings Inc., incorporated on June 24, 2004, is engaged in the marketing, sales, and distribution of over-the-counter health care products to mass merchandisers; drug stores; supermarkets; and club, convenience, and dollar stores in North America (the United States and Canada), in Australia, and in certain other international markets. The company operates through two segments: North American over-the-counter (OTC) health care and International OTC health care.

YPSOMED HOLDING AG (SWX: YPSN)

Total Revenue: 453.8M CHF

Market Cap: 1.78B CHF

R&D Spend: 41.9M CHF

Employee Size: 1,604

Website: https://www.ypsomed.com/

Ypsomed Holding AG is a Switzerland-based holding company engaged in the manufacture of injection pens for pharmaceutical and biotech companies. The company develops and manufactures injection systems for custom-made self-administration, and it markets pen needles for the treatment of diabetes, growth disorders, or infertility. The company operates two business segments: Injection Systems and Diabetes Care. In the Injection Systems segment, the company's Ypsomed Delivery Systems (YDS) offer a range of ready-to-use injection systems for pharmaceutical and biotech companies to administer drugs or to develop and manufacture them in line with customer requirements. The Diabetes Care segment markets products such as pen needles or insulin pumps to diabetes patients and to doctors and health insurance providers. The company operates its production sites in Burgdorf, Solothurn, Grenchen and Tabor and has sales and distribution network across Europe.

GLAUKOS CORPORATION (NYSE: GKOS)

Total Revenue: $236.98M USD

Market Cap: $1.61B USD

R&D Spend:  $68.3M USD

Employee Size: 600

Website: http://www.glaukos.com/

Glaukos Corporation, incorporated on July 14, 1998, is an ophthalmic medical technology company. The company focuses on the development and commercialization of products and procedures for the treatment of glaucoma. It has developed the microinvasive glaucoma surgery (MIGS) to serve as an alternative to the traditional glaucoma treatment and management paradigm. It offers iStent, a MIGS device. The iStent is a micro-bypass stent inserted through a small corneal incision made during cataract surgery and placed into Schlemm's canal, a circular channel in the eye that collects aqueous humor and delivers it back into the bloodstream. It is developing three additional pipeline products: the iStent Inject, the iStent Supra, and the iDose. The iStent Inject includes two stents preloaded in an autoinjection inserter. The iStent Supra is designed to access an alternative drainage space within the eye. iDose is a drug delivery system that is designed to be implanted in the eye to continuously deliver therapeutic levels of medication for extended periods to lower intraocular pressure in glaucoma patients.

ATRICURE INC (NASDAQ: ATRC)

Total Revenue: $201.6M USD

Market Cap: $1.57B USD

R&D Spend: $34.7M USD

Employee Size: 620

Website: http://www.atricure.com/

AtriCure Inc., incorporated on October 31, 2000, is an atrial fibrillation (AFib) solutions company. The company develops, manufactures, and sells devices designed primarily for the surgical ablation of cardiac tissue, as well as systems designed for the exclusion of the left atrial appendage. The company’s  Isolator Synergy Ablation System was designed for the treatment of persistent and long-standing persistent forms of AFib in patients undergoing certain open concomitant procedures. The company offers various minimally invasive ablation devices and access tools to facilitate less invasive cardiac and thoracic surgery.

STAAR SURGICAL COMPANY (NASDAQ: STAA)

Total Revenue: $150.2M USD

Market Cap: $1.42B USD

R&D Spend: $25.2M USD

Employee Size: 475

Website: http://www.staar.com/

STAAR Surgical Company (STAAR), incorporated on April 3, 1986, designs, develops, manufactures, and sells implantable lenses for the eye, as well as delivery systems used to deliver the lenses into the eye. The company operates in the ophthalmic surgical market segment. The company's principal products are intraocular lenses (IOLs) used in cataract surgery and implantable collamer lenses (ICLs) used in refractive surgery. The company makes lenses used in corrective or refractive surgery across the world and makes lenses for use in surgery that treats cataracts.

CARDIOVASCULAR SYSTEMS INC. (NASDAQ: CSII)

Total Revenue: $217M USD

Market Cap: $1.39B USD

R&D Spend: $26.8M USD

Employee Size: 652

Website: http://www.csi360.com/

Cardiovascular Systems Inc., incorporated on December 6, 2000, is a medical technology company. The company is engaged in treating patients suffering from peripheral and coronary artery diseases, including those with arterial calcium. The company develops an orbital atherectomy technology for both peripheral and coronary commercial applications. Its peripheral artery disease (PAD) systems are catheter-based platforms capable of treating a range of plaque types in leg arteries both above and below the knee.

ARJO AB (STO: ARJO-B)

Total Revenue: 8.21B SEK

Market Cap: 13.89B SEK

R&D Spend: 201M SEK

Employee Size: 6,123

Website: https://www.arjo.com/int/

Arjo AB is a medical device company that manufactures medical devices, services, and solutions aimed to improve quality of life for people with reduced mobility and age-related health issues. The company sells products in over 100 countries throughout North America and Western Europe, and other regions. The company is headquartered in Malmö, Sweden.

ATRION CORPORATION (NASDAQ: ATRI)

Total Revenue: $152.4M USD

Market Cap: $1.22B USD

R&D Spend: $5.5M

Employee Size: 570

Website: http://www.atrioncorp.com/

Atrion Corporation (Atrion), incorporated on December 30, 1996, is engaged in developing and manufacturing products primarily for medical applications. The company's medical products range from fluid delivery devices to ophthalmic and cardiovascular products. Its fluid delivery products include valves that promote infection control and needle safety. It has developed a range of valves designed to fill, hold, and release controlled amounts of fluids or gasses on demand for use in various intubation, intravenous, catheter, and other applications in areas such as anesthesia and oncology.

PAUL HARTMANN AG (OTC: PLHNF)

Total Revenue: €2.12B EUR

Market Cap: €1.1B EUR

R&D Spend: €478.86M EUR

Employee Size:  11,027

Website: https://www.hartmann.info/en-corp

Paul Hartmann AG is headquartered in Heidenheim, Germany. The company manufactures personal hygiene and medical products and operates in Europe, Asia, North America, South America, Africa, and Australia. The company operates through four segments, which are Wound Management, Incontinence Management, Infection Management, and Other Group Activities.

LUMINEX CORP. (NASDAQ: LMNX)

Total Revenue: $315.8M USD

Market Cap: $1.19B USD

R&D Spend: $47.2M USD

Employee Size: 1,141

Website: https://www.luminexcorp.com/

Luminex Corporation, incorporated on June 19, 1998, develops, manufactures, and sells biological testing technologies with applications throughout the diagnostics, pharmaceutical, and life sciences industries. The company's products are focused on the molecular diagnostic testing market, which includes human genetics, personalized medicine, and infectious disease segments.

MESA LABORATORIES INC. (NASDAQ: MLAB)

Total Revenue: $103.13M USD

Market Cap: $1.1B USD

R&D Spend: $3.5M USD

Employee Size: 366

Website: http://www.mesalabs.com/

Mesa Laboratories Inc., incorporated on March 26, 1982, is focused primarily on quality control products and services. The company operates through four segments: Instruments, Continuous Monitoring, Biological Indicators, and Cold Chain. The Instruments division designs, manufactures, and markets quality control instruments and disposable products utilized in connection with the health care, pharmaceutical, food and beverage, medical device, industrial hygiene, environmental air sampling, and semiconductor industries.

CRYOLIFE INC. (NYSE: CRY)

Total Revenue: $262.8M USD

Market Cap: $990M USD

R&D Spend: $23.6M USD

Employee Size: 1,100

Website: http://www.cryolife.com/

CryoLife’s mission is to restore patients’ health and quality of life by delivering innovative technologies. CryoLife is one of the world’s leading contemporary medical device companies, providing preserved human tissues for cardiac and vascular surgeries; mechanical heart valves for aortic or mitral valve replacement; surgical adhesives and sealants; cardiac lasers for treatment of refractory angina; and state-of-the-art technology and surgical training in adult and pediatric cardiovascular surgery.

Since its inception in 1984, it is estimated that CryoLife’s products and tissues have been implanted in over 1 million patients worldwide.

NATUS MEDICAL INC. (NASDAQ: BABY)

Total Revenue: $495.1M USD

Market Cap: $940M USD

R&D Spend: $58.73M USD

Employee Size: 1,484

Website: https://natus.com

Natus Medical Incorporated (Natus) offers medical equipment, software, supplies, and services for the diagnosis, monitoring, and treatment of impairments and disorders affecting newborns, nerves, muscles, balance, mobility, hearing, and the brain. Natus is organized into three strategic business units: neuro, newborn care, and otometrics.

BIOTAGE AB (CPH: BIOT)

Total Revenue: $1.1B SEK

Market Cap: $7.739B SEK

R&D Spend: $78.6M SEK

Employee Size: 464

Website: http://www.biotage.com/

Biotage AB is a Sweden-based company that develops and sells systems, consumables, and services in the field of life sciences. Its customers include companies within the pharmaceutical and biotechnology industries, companies within the food industry, and institutions within academia. The company offers systems and services within three areas: analytical chemistry, organic chemistry, and industrial resins. Biotage’s offering within analytical chemistry consists of consumables with related applications to extract selected substances from various types of samples. The company’s offering within organic chemistry includes products for pharmaceutical development based on both small molecules and peptides. The company’s offering related to industrial resins is composed of polymer-based resins and research services that lead to the development and manufacture of polymer-based materials.

INTERSECT ENT INC. (NASDAQ: XENT)

Total Revenue: $108.47M USD

Market Cap: $730M USD

R&D Spend: $19.26M USD

Employee Size: 393

Website: http://www.intersectent.com/

Intersect ENT Inc., incorporated on October 6, 2003, is a commercial-stage drug-device company. The company develops drugs for patients with ear, nose, and throat (ENT) conditions. The company has developed a drug-releasing bioabsorbable implant technology that enables targeted and sustained release of therapeutic agents. This targeted drug delivery technology is designed to allow ENT physicians to manage patient care. The company's commercial products are the PROPEL and PROPEL Mini drug-releasing implants for patients undergoing sinus surgery to treat chronic sinusitis.

ORTHOFIX INTERNATIONAL N.V. (NYSE: OFIX)

Total Revenue: $453M USD

Market Cap: $700M USD

R&D Spend: $33.21M USD

Employee Size: 954

Website: http://www.orthofix.com/

Orthofix International N.V. (Orthofix), incorporated on October 19, 1987, is a global medical device company. The company is focused on providing reconstructive and regenerative orthopedic and spine solutions to physicians. The company operates through four segments: BioStim, Biologics, Extremity Fixation, and Spine Fixation. The company provides an array of implants designed for use primarily in cervical, thoracic, and lumbar fusion surgeries. These implants are made of either metal or a thermoplastic compound called Polyetheretherketones (PEEK). The company also provides an array of implants designed for use primarily in cervical, thoracic, and lumbar fusion surgeries.

ADVANCED MEDICAL SOLUTIONS GROUP PLC (LON: AMS)

Total Revenue: £102.6M GBP

Market Cap: £545.82 GBP

R&D Spend: £3.07M GBP

Employee Size: 600

Website: http://www.admedsol.com/

Advanced Medical Solutions Group PLC, together with its subsidiaries, designs, develops, manufactures, and distributes products for the advanced wound care, surgical, and wound-closure markets worldwide. It operates through two segments: Branded and OEM. The company offers natural and synthetic polymers for use in advanced wound-care dressings under the ActivHeal brand; medical adhesives for closing and sealing tissue under the LiquiBand brand; and sutures and hemostats for the medical device market under the RESORBA brand.

CONSORT MEDICAL PLC (LON: CSRT)

Total Revenue: £305.1M GBP

Market Cap: £502.1M GBP

R&D Spend: £7.9 GBP

Employee Size: 2,000

Website: http://www.consortmedical.com/

Consort Medical PLC is a contract development and manufacturing organization (CDMO). The company's principal activities include the design, development, and manufacture of medical drug delivery devices and services for the pharmaceutical industry. The company operates through two segments: Bespak and Aesica. Bespak's core business is the manufacture of inhaled drug delivery devices for life sciences partners, and its operations are based in the United Kingdom. The Aesica business manufactures and sells active pharmaceutical ingredients (API), formulated pharmaceutical products, and packaging services to the pharmaceutical industry, and its operations are based in the United Kingdom and Europe. It offers its services to customers, such as pharmaceutical companies. Its device products include metered-dose inhalers, dry powder devices, actuators, dose counters, disposable autoinjectors, nasal devices, and point-of-care diagnostics devices.

LEMAITRE VASCULAR INC. (NASDAQ: LMAT)

Total Revenue: $105.56M USD

Market Cap: $580M USD

R&D Spend: $8.1M USD

Employee Size: 483

Website: http://www.lemaitre.com/

LeMaitre Vascular Inc., incorporated on June 15, 1998, is a provider of medical devices for the treatment of peripheral vascular disease. The company develops, manufactures, and markets medical devices and implants used primarily in the field of vascular surgery. It is engaged in the design, marketing, sales, and technical support of medical devices and implants. The company's product lines include valvulotomes, balloon catheters, carotid shunts, biologic vascular patches, radiopaque marking tape, anastomotic clips, remote endarterectomy devices, laparoscopic cholecystectomy devices, prosthetic vascular grafts, biologic vascular grafts, and powered phlebectomy devices.

AXOGEN INC. (NASDAQ: AXGN)

Total Revenue: $106.71M USD

Market Cap: $470M USD

R&D Spend: $17.5M USD

Employee Size: 297

Website: http://www.axogeninc.com/

Axogen Inc., incorporated on June 20, 1977, offers surgical solutions for peripheral nerve injuries. The company provides products and education to improve surgical treatment algorithms for peripheral nerve injuries. Its portfolio of products includes Avance Nerve Graft, Axoguard Nerve Connector, Axoguard Nerve Protector, and Avive Soft Tissue Membrane. Along with these core surgical products, the company also offers the Axotouch Two-Point Discriminator, and the AcroVal Neurosensory and Motor Testing System. These evaluation and measurement tools assist health care professionals in detecting changes in sensation; assessing return of sensory, grip, and pinch function; evaluating treatment interventions; and providing feedback about nerve function to patients.

ANGIODYNAMICS INC. (NASDAQ: ANGO)

Total Revenue: $344.28M USD

Market Cap: $440M USD

R&D Spend: $25.45M USD

Employee Size: 1,145

Website: http://www.angiodynamics.com/

AngioDynamics Inc., incorporated on July 30, 1992, designs, manufactures, and sells a range of medical, surgical, and diagnostic devices used by professional health care providers for vascular access, for the treatment of peripheral vascular disease, and for use in oncology and surgical settings. The company's devices are used in minimally invasive, image-guided procedures. The company offers products within three product groupings: Peripheral Vascular, Vascular Access, and Oncology/Surgery.

OWENS & MINOR INC. (NYSE: OMI)

Total Revenue: $9.83B USD

Market Cap: $380M USD

R&D Spend: None

Employee Size: 17,900

Website: https://www.owens-minor.com/

Owens & Minor Inc. is a global health care logistics company founded and headquartered in Virginia. Owens & Minor was founded in 1882 and now operates on four continents. In 2018, the company acquired Halyard Health Inc. for $710 million, the largest Owens & Minor acquisition to date. Owens & Minor has been a Fortune 500 company for 25 years, most recently ranked at 317.

ORASURE TECHNOLOGIES INC. (NASDAQ: OSUR)

Total Revenue: $181.74M USD

Market Cap: $380M USD

R&D Spend:$16.3M USD

Employee Size: 347

Website: http://www.orasure.com

OraSure Technologies Inc. (OraSure), incorporated on May 5, 2000, is involved in the development, manufacture, marketing, and sale of oral fluid diagnostic products and specimen collection devices using its technologies, as well as other diagnostic products, including immunoassays and other in vitro diagnostic tests that are used on other specimen types. The company operates in two segments: OSUR and DNAG. OSUR consists of the development, manufacture, and sale of diagnostic products, specimen collection devices, and medical devices. DNAG consists primarily of the development, manufacture, and sale of oral fluid collection devices that are used to collect, stabilize, and store samples of genetic material for molecular testing.

CUTERA INC. (NASDAQ: CUTR)

Total Revenue: $162.7M USD

Market Cap: $330M  USD

R&D Spend: $14.3M USD

Employee Size: 402

Website: http://www.cutera.com/

Cutera Inc., incorporated on August 10, 1998, is a medical device company. The company is engaged in the design, development, manufacture, marketing, and servicing of laser and other energy-based aesthetics systems for practitioners across the world. The company offers products based on product platforms, such as Enlighten, Excel HR, TruSculpt, Excel V, and Xeo, each of which enables physicians and other practitioners to perform aesthetic procedures for customers. Each of its laser and other energy-based platforms consists of one or more handpieces and a console that incorporates control system software, high voltage electronics, a universal graphical user interface, and a laser or another energy-based module.

UTAH MEDICAL PRODUCTS INC. (NASDAQ: UTMD)

Total Revenue: $41.9M USD

Market Cap: $320M USD

R&D Spend: $454K USD

Employee Size: 173

Website: http://www.utahmed.com/

Utah Medical Products Inc. (UTMD), incorporated on April 21, 1978, is engaged in the business of producing medical devices that are disposable and are for hospital use. The company's product categories include labor and delivery, obstetrics; neonatal intensive care; gynecology/urology/electrosurgery; and blood pressure monitoring. UTMD markets a range of medical devices used in care areas, such as the neonatal intensive care unit (NICU), the labor and delivery (L&D) department, and the women's health center in hospitals, as well as products sold to outpatient clinics and physicians’ offices. Domestically, UTMD's medical devices are sold directly to clinical end-user facilities by the company's own direct sales representatives and independent manufacturers' representatives.

RTI SURGICAL INC. (NASDAQ: RTIX)

Total Revenue: $290.9M USD

Market Cap: $280M USD

R&D Spend: $14.4M USD

Employee Size: 891

Website: http://www.rtix.com/

RTI Surgical Inc. is a global surgical implant company providing surgeons with biologic, metal, and synthetic implants. It operates through the following business lines: Spine, Sports Medicine and Orthopedics, Surgical Specialties, Cardiothoracic, International, and Global Commercial. The Spine business line designs, manufactures, and distributes surgical implants, instruments, and biologics used in the treatment of conditions affecting the spine caused by degenerative conditions, deformities, or traumatic injury.

VIEWRAY INC. (ASX: VRAY)

Total Revenue: $81M USD

Market Cap: $280M USD

R&D Spend: $4.01M USD

Employee Size: 221

Website: http://www.viewray.com/

ViewRay Inc., incorporated in 2013, through its subsidiary ViewRay Technologies Inc., designs, manufactures, and markets MRIdian, the magnetic resonance imaging (MRI)-guided radiation therapy system to image and treat cancer patients simultaneously. The company offers radiation therapy technology combined with magnetic resonance imaging. MRIdian integrates MRI technology, radiation delivery, and the company's software to locate, target, and track the position and shape of soft-tissue tumors while radiation is delivered.

BIOLIFE SOLUTIONS INC. (NASDAQ: BLFS)

Total Revenue: $19.7M USD

Market Cap: $280M USD

R&D Spend: $315K USD

Employee Size:54

Website: https://biolifesolutions.com/

BioLife Solutions Inc. (BioLife), incorporated on March 25, 1998, is engaged in developing, manufacturing, and marketing a portfolio of biopreservation tools and services for cells, tissues, and organs, including clinical grade cell and tissue hypothermic storage, and cryopreservation freeze media and a related cloud-hosted biologistics cold chain management application for shippers.

INVACARE CORPORATION (NYSE: IVC)

Total Revenue: $972.34M USD

Market Cap: $270M USD

R&D Spend: $17.3M USD

Employee Size: 4,200

Website: http://www.invacare.com/

Invacare Corporation, incorporated on March 23, 1971, is a manufacturer and distributor of medical equipment used in nonacute care settings. The company designs, manufactures, and distributes medical devices that help people move, breathe, rest, and perform essential hygiene. The company's geographical segments are Europe, North America, and Asia/Pacific. The company provides medical device solutions for congenital, acquired, and degenerative ailments.

SEASPINE HOLDINGS CORPORATION (NASDAQ: SPNE)

Total Revenue: $143M USD

Market Cap: $270M USD

R&D Spend: $3.2M USD

Employee Size: 386

Website: http://www.seaspine.com/

SeaSpine Holdings Corporation, incorporated on February 12, 2015, is a medical technology company. The company is focused on the design, development, and commercialization of surgical solutions for the treatment of patients suffering from spinal disorders. The company operates through the development, manufacture, and marketing of orthobiologics and spinal-fusion hardware segment. The company has a portfolio of orthobiologics and spinal-fusion hardware solutions to meet the varying combinations of products that neurosurgeons and orthopedic spine surgeons need to perform fusion procedures in the lumbar, thoracic, and cervical spine.

IRADIMED CORPORATION (NASDAQ: IRMD)

Total Revenue: $30.4M USD

Market Cap: $270M USD

R&D Spend: $1.5M USD

Employee Size: 95

Website: http://www.iradimed.com/

IRadimed Corporation (IRADIMED), incorporated on April 8, 2014, develops, manufactures, markets, and distributes magnetic resonance imaging (MRI)-compatible products and provides nonmagnetic intravenous (IV) infusion pump systems. The company operates through the development, manufacture, and sale of MRI-compatible products and IV infusion pump systems for use by hospitals and acute care facilities during MRI procedures. The company's MRidium MRI-compatible IV infusion pump system has been designed with nonferrous parts, a nonmagnetic ultrasonic motor, and other features in order to deliver anesthesia and other IV fluids during various MRI procedures. Each system consists of an MRidium MRI-compatible IV infusion pump, a nonmagnetic mobile stand, and disposable IV tubing sets.

TRISTEL PLC (LON: TSTL)

Total Revenue: £26.17M GBP

Market Cap: £193.6M GBP

R&D Spend: None

Employee Size: 111

Website: http://www.tristel.com/

Tristel PLC is a United Kingdom-based manufacturer of infection prevention and contamination control products. The company's technology is a chlorine dioxide formulation. The company operates through three segments: human health care, animal health care, and contamination control. The human health care segment is engaged in the manufacture, development, and sale of infection control and hygiene products, which include products that are used primarily for infection control in hospitals; the segment’s products are marketed under the brand Tristel. The Animal Healthcare segment relates to the manufacture and sale of disinfection and cleaning products for veterinary and animal welfare sectors; the segment’s products are marketed under the brand Anistel. The Contamination Control segment addresses the pharmaceutical and personal care product manufacturing industries.

GENMARK DIAGNOSTICS INC. (NASDAQ: GNMK)

Total Revenue: $70.75M USD

Market Cap: $200M USD

R&D Spend: $27.93M USD

Employee Size: 477

Website: http://www.genmarkdx.com/

GenMark Diagnostics Inc., incorporated on February 12, 2010, is a molecular diagnostics company. The company is focused on developing and commercializing multiplex molecular tests that aid in the diagnosis of complex medical conditions. The company develops and commercializes multiplex molecular tests based on its eSensor electrochemical detection technology. It offers four Food and Drug Administration (FDA)-cleared diagnostic tests, which run on its XT-8 instrument: the Respiratory Viral Panel; the Cystic Fibrosis Genotyping Test; the Warfarin Sensitivity Test; and the Thrombophilia Risk Test.

NEMAURA MEDICAL INC. (NASDAQ: NMRD)

Total Revenue: None

Market Cap: $159.2M USD

R&D Spend: $2.29B USD

Employee Size: 10

Website: http://www.nemauramedical.com/

Nemaura Medical Inc. is a medical technology company that discovers, develops, and commercializes specialty medical devices. It provides SugarBEAT, a noninvasive continuous glucose monitoring device for use by persons with type 1 and type 2 diabetes, as well as for screening prediabetic patients. 

FONAR CORPORATION (NASDAQ: FONR)

Total Revenue: $81.5M USD

Market Cap: $130M USD

R&D Spend: $1.7M USD

Employee Size: 525

Website: http://www.fonar.com/

Fonar Corporation (Fonar), incorporated on July 17, 1978, is engaged in the business of designing, manufacturing, selling, and servicing magnetic resonance imaging (MRI) scanners, which utilize MRI technology for the detection and diagnosis of human disease, abnormalities, injuries, and other medical conditions. The company operates its business through two segments: Medical Equipment, and Physician Management and Diagnostic Services. Its Medical Equipment segment is conducted through Fonar. Its Physician Management and Diagnostic Services segment is conducted through its subsidiary Health Management Company of America (HMCA).

HARVARD BIOSCIENCE INC. (NASDAQ: HBRO)

Total Revenue: $120.77M USD

Market Cap: $110M USD

R&D Spend:$11M USD

Employee Size: 547

Website: http://www.harvardbioscience.com/

Harvard Bioscience Inc., incorporated on October 8, 2000, is a developer, manufacturer, and marketer of a range of scientific instruments, systems, and lab consumables used for basic research, drug discovery, and clinical and environmental testing. The company's products are sold to thousands of researchers in over 100 countries through its global sales organization, websites, and catalogs and through distributors. The company's product range is organized into three commercial product families: Cell and Animal Physiology (CAP), Lab Products and Services (LPS), and Molecular Separation and Analysis (MSA). The company sells these products under brand names, including Harvard Apparatus, KD Scientific, Denville Scientific, AHN, Hoefer, Biochrom, BTX, Warner Instruments, MCS, HEKA, Hugo Sachs Elektronik, Panlab, Coulbourn Instruments, TBSI, and CMA Microdialysis. The company's products consist of instruments, consumables, and systems that are made up of various individual products.

CHINA GRAND PHARMACEUTICAL AND HEALTHCARE HOLDINGS LIMITED

Total Revenue: $5.95B HKD

Market Cap: $310.8M HKD

R&D Spend: $137.4M HKD

Employee Size: 8,0006

Website: http://www.chinagrandpharm.com/

China Grand Pharmaceutical and Healthcare Holdings Limited is a Hong Kong-based investment holding company principally engaged in the manufacture of pharmaceuticals. The main businesses of the company include the research and development, manufacture, and sale of pharmaceutical products, medical products, chemical products, and health care products. The products of the company include preparations, raw materials, medical devices, and health care products, as well as agricultural and fine chemicals. It mainly focuses on ophthalmic, cardiovascular, and antibacterial products.  

TRANSENTERIX INC. (NYSE: TRXC)

Total Revenue: $24.1M USD

Market Cap: $29.43M USD

R&D Spend: $21.8M USD

Employee Size: 189

Website: https://transenterix.com/

TransEnterix Inc., incorporated on August 19, 1988, is a medical device company. The company is focused on the development and commercialization of the ALF-X Surgical Robotic System (the ALF-X System), a multiport robotic system; and the SurgiBot System, a single-port, laparoscopic surgical platform. The company also develops and manufactures laparoscopic surgical instruments such as scissors, graspers, clip appliers, and suction and irrigation instruments used in abdominal surgery.

The company's ALF-X System is a multiport robotic surgery system, which allows multiple robotic arms to control instruments and a camera. The system features advanced technology to enable surgeons with haptic feedback and the ability to move the camera through eye movement.

ENDOLOGIX INC. (NASDAQ: ELGX)

Total Revenue: $156.4M USD

Market Cap: $20M USD

R&D Spend: $20.7M USD

Employee Size: 528

Website: http://www.endologix.com/

Endologix Inc., incorporated on June 2, 1993, is engaged in developing, manufacturing, marketing, and selling medical devices for the treatment of aortic disorders. The company's products are intended for the treatment of abdominal aortic aneurysms (AAA). The AAA products are built on one of two platforms: either traditional minimally invasive endovascular repair (EVAR) or endovascular sealing (EVAS), its solution for sealing the aneurysm sac while maintaining blood flow through blood-flow lumens.

B. BRAUN MELSUNGEN AG (PRIVATELY HELD)

Total Revenue: €6.9B EUR

Market Cap: Privately Held

R&D Spend: €318M EUR

Employee Size: 62,855

Website: http://www.bbraun.com/

Braun is one of the world's leading providers and manufacturers of health care solutions today. Every service that B. Braun provides incorporates the entirety of the company’s knowledge and skills, the company's deep understanding of users' needs, and extensive expertise. With its constantly growing portfolio of effective medical care solutions, B. Braun makes a substantial contribution toward protecting and improving people's health. In total, the B. Braun product range comprises 5,000 different products, 95 percent of which are manufactured by the company.

FREE RESOURCE: Click here to download a PDF chart of the top 100 medical device companies in the world.

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